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WebApr 13, 2024 · In vitro functional activities of five P450 2A13 genetic variations (R257C, 133_134insT, R101Q, I331T, and R257C/I331T) in P450 1A13*2, *3, *4, and *10 alleles are examined to understand the consequences of P4502A13 polymorphism in bioactivation of many tobacco-derived carcinogens. ABSTRACT Humans possess three cytochrome … WebDownload the latest software and drivers from Konica Minolta Support and Downloads. You can also find a sales location, request a quote or contact customer care. WebApr 1, 2006 · P450s 2A6 and 2A13 are thought to be the primary human P450 enzymes responsible for the in vivo metabolism of nicotine and NNK, respectively. In vitro, BITC and PEITC efficiently inhibited P450 2A6- and 2A13-mediated coumarin 7-hydroxylation. The inhibition of P450 2A6 and 2A13 by BITC was non-competitive with KI's of 4.1 and 1.3 … n65w34109 timberline dr oconomowoc wi 53066