Human cgas uniprot
WebWe would like to show you a description here but the site won’t allow us. WebThe cyclic GMP-AMP synthase (cGAS)–cGAMP–STING pathway plays a key role in innate immunity, with cGAS sensing both pathogenic and mislocalized DNA in the cytoplasm. Human cGAS (h-cGAS) constitutes …
Human cgas uniprot
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WebUniProt. Q8TDL6 has been merged into O00391. You have automatically been redirected. WebProduct Details. The recombinant 6xHis-SUMO-tagged cyclic GMP-AMP synthase (CGAS) protein was expressed in E.coli. Amino acid residues Gly161-Phe522 of human CGAS protein are contained in this recombinant protein. The SDS-PAGE measured its purity of over 90%, and the CGAS protein migrated to the molecular mass of about 50-61 kDa on …
WebFeb 28, 2024 · Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. The cyclic GMP-AMP … WebSchool of Health and Human Sciences Location: 401 Mary Channing Coleman Bldg., 1408 Walker Ave., Greensboro, NC 27412 Mailing Address: PO Box 26170, Greensboro, NC …
WebJul 12, 2024 · cGAS is a nucleotidyltransferase that consists of an unstructured flexible N-terminal domain of about 160 amino acids length, followed by a bilobal C-terminal catalytic domain of the Mab21 fold containing a zinc-binding dimerization motif (zinc-thumb, Fig 2A ). cGAS is activated by DNA-dependent dimerization and multimerization (Fig 2B ). WebMar 29, 2024 · cGAS Antibody (D-9) is an IgG2a κ mouse monoclonal cGAS antibody that detects cGAS of human origin by WB, IP, IF, IHC(P) and ELISA. cGAS Antibody (D-9) is available as the non-conjugated anti-cGAS antibody form, as well as multiple conjugated forms of anti-cGAS antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor …
WebActivated by direct binding to LPS without the need of an upstream sensor. Does not directly process IL1B. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
WebCyclic GMP-AMP synthase (cGAS) is a signaling enzyme in human cells that controls immune-sensing of cytosolic DNA. The recent discoveries of diverse structural homologs of cGAS in animals and bacteria reveal that cGAS-like signaling is surprisingly ancient and widespread in biology. tatuaje zulema ojoWebMay 29, 2024 · Human cGAS (h-cGAS) constitutes an important drug target for control of antiinflammatory responses that can contribute to the onset of autoimmune diseases. Recent studies have established... bateria 14vWebAug 24, 2024 · The human cGAS protein (UniProt: Q8N884) was added, as well as the human oligoadenylate synthase genes (UniProt: P00973, P29728 and Q9Y6K5); these … tatuaje zeusWebIn contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to … tatuaje zenitsuWebJul 12, 2024 · between cGAS and the nucleosomal DNA. Six mouse cGAS–NCP and five human cGAS–NCP structural analyses yielded complexes with stoichiometries of either 1:1, 2:1, 1:2, or 2:2 (Fig 4A). Each NCP has two acidic patches related by a twofold symmetry, and since cGAS binding to the acidic patch does not induce apparent conformational … bateria 150ah heliarWeb14 hours ago · Background: Detection of viruses by host pattern recognition receptors induces the expression of type I interferon (IFN) and IFN-stimulated genes (ISGs), which suppress viral replication. Retroviruses such as HIV-1 are subject to sensing by both RNA and DNA sensors, and whether there are any particular features of the viral genome or … tatuaze dla kobiet na nogeWebJul 14, 2024 · A role in sensing long dsRNA suggests that the function of Dm -cGLR1 is to control a downstream immune response in Drosophila. In human cells, cGAS synthesizes the nucleotide second messenger 2 ... tatuaze dla kobiet na reke