Small cholangiocyte
Webb25 aug. 2024 · Small cell cholangiocytes (SMCCs) were plated at 2 × 10 5 cells/well in a six-well plate and transfected with 2.5 µg control or Wnt7b plasmid, described elsewhere, and 50 µM negative or β-catenin small interfering RNA (siRNA; Thermo Fisher Scientific, Waltham, MA) using Lipofectamine 3000 (Invitrogen, Carlsbad, CA), as per the …
Small cholangiocyte
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WebbSmall and large cholangiocytes express HRH1, CaMK I, and CaMK II. Small (but not large) cholangiocytes proliferate in response to HTMT dimaleate and are blocked by … Webb18 okt. 2010 · Small and large bile ducts and cholangiocytes expressed all AR receptor subtypes. Small (but not large) cholangiocytes respond to phenylephrine with increased proliferation via the activation of IP 3 /Ca 2+ -dependent signaling. Phenylephrine stimulated the production of intracellular IP 3.
Webb11 sep. 2024 · Small and large intrahepatic bile ducts consist of small and large cholangiocytes, respectively, and these cholangiocytes have different morphology and functions. The gastrointestinal peptide hormone, secretin (SCT) that binds to secretin receptor (SR), is a key mediator in cholangiocyte pathophysio … WebbSmall and large cholangiocytes differ in nuclear-to-cytoplasmic ratio; small cholangiocytes have a higher ratio, suggesting they are less differentiated and have more capacity for …
Webb21 dec. 2024 · Specifically, only small cholangiocytes proliferate when stimulated with a specific histamine receptor agonist (HRH1); however, small cholangiocytes can also acquire large cholangiocyte phenotypes after insult such as GABA treatment ( Francis et al., 2008; Mancinelli et al., 2013 ). Webb5 maj 2024 · ( a) SBEC cholangiocytes transfected with RhoU/Wrch1 or Hey2 plasmids and with an empty vector as a control. Cells were immunostained for RhoU/Wrch1 or Hey2 (red) 48 h after transfection. Nuclei...
WebbCa(2+)-dependent protein kinase C (PKC) regulates small cholangiocyte function. Because gamma-aminobutyric acid (GABA) affects cell functions by activation of both Ca(2+) signaling and inhibition of AC, we sought to develop an in vivo model characterized by large cholangiocyte damage and proliferation of small ducts.
WebbDifferences between small and large cholangiocytes are summarized in Table 5. These phenotypic differences FIG. 3. Biliary tree, bile duct, cholangiocytes, and duct bile … list of all nft tokensWebb11 sep. 2024 · Small and large intrahepatic bile ducts consist of small and large cholangiocytes, respectively, and these cholangiocytes have different morphology and functions. The gastrointestinal peptide ... images of john wayne gacyWebb9 feb. 2024 · Collectively, DUOX2⁺ACE2⁺ small cholangiocytes are pathogenic targets in PBC, and preservation of DUOX2⁺ACE2⁺ cholangiocytes and targeting anti-pIgR autoantibodies may be valuable strategies for... list of all nfl teams in alphabetical orderWebb11 nov. 2024 · With this level of maturation, these cholangiocytes are amenable for testing the efficacy of cystic fibrosis drugs and for studying the role of cilia in cholangiocyte … images of john tylerWebbCholangiocytes carry out this function through a complex sensing mechanism mediated by a series of receptors, ion channels and sensory signaling molecules found on a structure known as a primary cilia that extends from the apical membrane of the cell into the lumen of the bile duct3. images of john piperWebb9 feb. 2024 · Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of PBC remains unclear despite being characterized as an … images of john sarkisianWebbThis cell line is aneuploid, will form colonies in soft agar and retains small cell carcinoma morphology and ultrastructure as well as APUD cell characteristics. The cells grow in aggregates, thus cell counts are not accurate. The cells stain positively for cytokeratins. The line can be adapted to grow in shaker flask or spinner flask systems. The N-myc … images of john travolta saturday night fever