Trichoplein
WebApr 1, 2012 · Trichoplein shows a low degree of sequence similarity to trichohyalin, plectin, and myosin heavy chain, and colocalizes with CK8/18 filaments in HeLa cells . Trichoplein may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells . Albatross ... Webケラチン結合蛋白質Trichopleinの中心体における機能解析(Trichoplein, a keratin binding protein, is a functional component of centrosomes) 大室 有紀[松山], 鄒 鵬, 猪子 誠人, 衣斐 美歩, 米村 重信, 林 裕子, 森 大輔, 広常 真治, 田村 淳, 月田 早智子, 稲垣 昌樹
Trichoplein
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WebApr 30, 2012 · Trichoplein or Aurora A knockdown failed to induce ciliogenesis or cell cycle arrest in HeLa cells, which, like many cancerous cell types, have a reduced tendency to form primary cilia. “We're now investigating whether Aurora A knockdown has different effects in various normal and cancer cell lines,” says Inagaki. WebThus, the EGFR–USP8–trichoplein–AURKA axis suppresses ciliogenesis under serum cultivation, and serum deprivation downregulates the EGFR-USP8 pathway, which triggers trichoplein degradation and AURKA inactivation, resulting in ciliogenesis. These results were the first to reveal the mechanism of serum starvation–induced ciliogenesis.
WebApr 30, 2012 · Trichoplein or AurA knockdown also induced G0/G1 arrest, but this phenotype was reversed when cilia formation was prevented by simultaneous knockdown of IFT-20. These data suggest that the trichoplein–AurA pathway is required for G1 progression through a key role in the continuous suppression of primary cilia assembly. Webcancers Article Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells Angela Lauriola 1,2, Andrea Martello 3,4, Sebastian Fantini 5, Gaetano Marverti 1, Tommaso Zanocco-Marani 5, Pierpaola Davalli 1, Daniele Guardavaccaro 2, Sabine Mai 6, Andrea Caporali 3,* and Domenico …
WebJun 14, 2024 · KCTD17 has also been reported to function as an adaptor of the cullin-3 ubiquitin ligase to mediate ubiquitination and degradation of trichoplein, which is a negative regulator of ciliogenesis. 32 Both neurons and astrocytes contain a primary cilium, and ciliogenesis has been reported to play an important role in brain development. 84 This ... Webtrichoplein (G-2): sc-515025 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com …
WebJan 19, 2024 · 1 Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.. 2 Research Center for Developmental Biology and Regenerative Medicine and. 3 Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.. 4 …
WebGeneral description. Trichoplein (TCHP) is also termed as mitostatin (TpMs). It is a keratin binding protein, which is partly located in the mitochondria. This gene is located on … dr who christmas specials 2020WebMar 15, 2011 · Trichoplein binds the centrosomal proteins Odf2 and ninein, which are localized at the distal to subdistal ends of the mother centriole. Trichoplein depletion … dr who christmas specials listWebTchp trichoplein, keratin filament binding 77832 Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 12683 Ifng interferon gamma 15978 Ppara peroxisome proliferator activated receptor alpha 19013 Itpr1 inositol 1,4,5-trisphosphate receptor 1 16438 Apoc2 apolipoprotein C-II 11813 dr who christmas specials songsWebDive into the research topics where David Mellis is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 1 Similar Profiles. P62 Chemical Compounds. 100%. anillin Medicine & Life Sciences. 85%. Endothelial Cells Medicine & Life Sciences. comfort inn and suites catoosa okWebDec 29, 2015 · Effects of trichoplein depletion on cell cycle regulators. Proliferating RPE1 cells were transfected with siRNA for control or trichoplein (#1 and #2), and then cultured for 72 h. The cell extracts were subjected to immunoblotting analysis with p27 Kip1, p53, p21 Cip1, p16 INK4a, trichoplein, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). comfort inn and suites charlottesvilleWebTrichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Authors - Andrea Martello. View Article. human: WB,IF: J Biol Chem. DAZ interacting protein 1 (Dzip1) phosphorylation by Polo-like kinase 1 (Plk1) regulates the centriolar satellites localization of the BBSome during the cell cycle. comfort inn and suites chambersburg paWebMar 21, 2024 · The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov … comfort inn and suites castleton ny